ea0014p231 | (1) | ECE2007
Glintborg Dorte
, Hermann Anne Pernille
, Hagen Claus
, Veldhuis Johannes
, Schmedes Anne
, Frystyk Jan
, Flyvbjerg Allan
, Andersen Marianne
Objective: To investigate the effect of pioglitazone on cortisol metabolism in PCOS.Design: Thirty insulin resistant PCOS patients were randomized to either 16 weeks of pioglitazone (30 mg/day) or placebo treatment. Before and after intervention, patients underwent 24 h 20 min.-integrated blood sampling for measurement of cortisol and 24 h excretion of cortisol, cortisone and steroid metabolites (cortisol, corticosteron, androgen, and 17-hydroxyprogester...